Multi-site study demonstrates efficacy of Draxxin® for SRD
A multi-site study of pigs with swine respiratory disease (SRD) demonstrates that one dose of Draxxin® (tulathromycin) not only lowers mortality, it can significantly improve treatment success and reduce total lung lesions.1
Draxxin is indicated for treatment as well as control of key pathogens associated with SRD. The multi-site study was conducted in Nebraska, Iowa, Minnesota and Saskatchewan, Canada. It included 455 mixed-sex commercial feeder pigs at farms with a history of SRD. When 15% of pigs in a pen met the criteria for SRD, they were randomly assigned to receive either one 2.5 ml/kg bodyweight intramuscular dose of saline as a control or Draxxin.
Draxxin is a rapidly absorbed antimicrobial that is extensively distributed in lung tissue and retained for a long duration,2 says Eva Jablonski, DVM, senior technical services veterinarian, Zoetis.
“To meet the criteria for SRD, pigs had respiratory and depression scores of ≥ 2 on a 0-to-3 scale and rectal temperatures of ≥ 104° F,” says Jablonski, noting that pigs from the saline and Draxxin groups were commingled. Treatment was considered successful if, by study-day 7, the animal was alive, had respiratory and depression scores ≤ 1 and a rectal temperature < 104º F (40º C).
Investigators observed the pigs twice daily to monitor their general health and clinically evaluated them on study-day 7. Nearly 60% of pigs that received Draxxin were successfully treated compared to 41% in the saline group (Figure 1), and the results were significant (p ≤ 0.05). Mortality was less in the Draxxin group (Figure 2). In addition, the percentage of total lungs with lesions was significantly lower in treated pigs — 6.6% compared to more than 13% in controls (p = 0.096), she says (Figure 3).
ab Percentages with diﬀerent superscripts diﬀer signiﬁcantly (p≤ 0.05)
ab Percentages with diﬀerent superscripts diﬀer signiﬁcantly (p= 0.096)
Lung sampling of pigs that died before the study started and at the end of the study revealed multiple SRD pathogens. Actinobacillus pleuropneumoniae was most often found, followed by Mycoplasma hyopneumoniae, Pasteurella multocida, Haemophilus parasuis and Bordetella bronchiseptica, Jablonski says.
“The results demonstrate that Draxxin can help producers control respiratory disease and cut losses when SRD is already present in a herd,” she says.
Important Safety Information for Swine: Withdraw Draxxin/Draxxin 25 ﬁve (5) days prior to slaughter in swine. Do not use in animals known to be hypersensitive to the product. Click here to see prescribing information for Draxxin.
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1 Date on file, Study Report No. 1123C-60-07-279, Zoetis, LLC.
2 Benchaoui HA, et al. Pharmacokinetics and lung tissue concentrations of tulathromycin in swine. J Vet Pharmacol Ther. 2004;27:203-210.
DISCOVERIES, Issue 11
Discoveries is a series of research news reports written by the editors of Pig Health Today on behalf of the US Pork Business of Zoetis.
Posted on December 21, 2021