fbpx
Sign up now!
Don't show this again
Download the report!Continue to Site >
or wait 7 secs

Thank you for confirming your subscription!

(And remember, if ever you want to change your email preferences or unsubscribe, just click on the links at the bottom of any email.)

We’re glad you’re enjoying Pig Health Today.
Access is free but you’ll need to register to view more content.
Already registered? Sign In
Tap to download the app
X
Share
X

REPORTS

Collect articles and features into your own report to read later, print or share with others

Create a New Report

Favorites

Read Later

Create a new report

Report title (required) Brief description (optional)
CREATE
X
NEXT
PORK POULTRY
follow us


You must be logged in to edit your profile.

Favorites Read Later My Reports PHT Special Reports
Pig Health Today is equipped with some amazing (and free) tools for organizing and sharing content, as well as creating your own magazines and special reports. To access them, please register today.
Sponsored by Zoetis

Pig Health Today | Sponsored by Zoetis

.

Large field trial showed Fostera Gold® PCV MH was effective against prevalent PCV2d genotype

Download the PDF

A large, commercial field trial conducted with Fostera® Gold PCV MH — the first and only commercial vaccine with porcine circovirus (PCV) genotypes 2a and 2b — showed it was also effective against PCV2d, the most prevalent genotype of the virus circulating among US swine herds.1

The field trial was conducted on a Midwest farm with 880 pigs from a high-health herd.2

More than 300 pigs in the study received Fostera Gold PCV MH as either one, 2-ml dose at 3 weeks of age or two, 1-ml doses administered 3 weeks apart starting at either 3 days or 3 weeks of age. The results were compared to pigs that received other commercially available PCV2 plus Mycoplasma hyopneumoniae (M. hyo) vaccines. An unvaccinated group received saline and served as the negative control.

After vaccination, all pigs in the trial were challenged first with M. hyo, then with PCV2d 1 week later.

‘Real-world’ conditions

“We wanted to test the new vaccine’s efficacy against M. hyo and PCV2d in a way that mimicked disease patterns seen on many farms,” said Rick Swalla, DVM, technical services veterinarian for Zoetis. “M. hyoand PCV2 disease often occur together and M. hyo potentiates PCV2 disease.”

An outbreak of swine influenza virus and Streptococcus suis at weaning inadvertently compounded the study’s real-world approach, he added.

Study results

Investigators considered several factors when they evaluated results.

One was viremia— the level of virus in the blood associated with clinical disease. PCV2 viremia was significantly lower (p< 0.05) with one- and two-dose regimens of Fostera Gold PCV MH compared to controls, Swalla reported.

Immunohistochemistry (IHC), which the veterinarian called “the gold standard for PCV2 diagnosis,” demonstrated that PCV2 was detected in 0% of pigs that received two doses of Fostera Gold PCV MH — one at weaning and the other 3 weeks later.

Regardless of vaccination protocol, pigs given Fostera Gold PCV MH had significantly lower (p< 0.05) lung lesionscores compared to pigs that received one dose of Ingelvac CircoFLEX® plus MycoFLEX® at weaning.

“In fact, pigs that received CircoFLEX plus MycoFLEX had numerically higher lung lesion scores than unvaccinated pigs and pigs in all other vaccine groups,” Swalla said.

Only one of the pigs that received Fostera Gold PCV MH had an injection-site reaction, which was negligible, Swalla noted.

Final weight

Most important from an economic standpoint was final weight, he said. By study-day 157, average weight in pigs that received one weaning dose of Fostera Gold PCV MH was 257 pounds, and 254 pounds in pigs that received two doses initiated at weaning.

These results were significantly higher (p< 0.05) compared to an average of 242 pounds for unvaccinated controls and numerically better than the average weight of 250 pounds for the Circumvent PCV-M G2 group and 251 pounds for the Inglevac CircoFLEX plus MycoFLEX group.

More insurance

According to 2017 data from Iowa State University’s Veterinary Diagnostic Laboratory, PCV2d is the most common genotype in US herds, and PCV2a and PCV2b are the next most prevalent.3 Commercial PCV2 vaccines that contain a single genotype — either 2a or 2b — help protect against PCV2, including 2d, but coverage is sometimes insufficient, resulting in PCV associated disease such as wasting, leading to poor performance, Swalla said.

Pigs vaccinated with Fostera Gold PCV MH develop antibodies against 2a and 2b. Research shows 2b and 2d are closely related, and the antibodies pigs develop against 2b also recognize 2d.4

Swalla noted that antibodies alone cannot fight the virus once it’s inside the cell. For that, cell-mediated immunity is needed. MetaStim®, the adjuvant in Fostera Gold PCV MH, is smooth yet stimulates both antibody and a strong cell-mediated immune response.

“Broader coverage resulting from the vaccine’s two genotypes provides additional insurance against evolving PCV2 virus,” Swalla said. In addition, the vaccine’s duration of immunity has been shown to be at least 23 weeks for both PCV and M. hyo, which protects most pigs until they reach market weight.

 

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. Ingelvac, Circoflex and Mycoflex are registered trademarks of Boehringer Ingelheim. Circumvent is a registered trademark of Merck Animal Health.

 

1 Personal communication between Darin Madson, PhD, and Rick Swalla, DVM.
2 Data on file, Study Report No. 16 PRGBIO-01-01, Zoetis LLC.
3 Personal communication between Darin Madson, PhD, and Rick Swalla, DVM.
4 Lekcharoensuk P , et al. Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) by using chimeric PCV1 and PCV2. J Virol. 2004 Aug;78(15):8135-8145.

 

 

DISCOVERIES, Issue 3
Discoveries is a series of  research news reports written by the editors of Pig Health Today on behalf of the US Pork Business of Zoetis.

FSTRA-00094
Feb 2018

 

 




Posted on April 20, 2018

tags: , , , ,
RELATED NEWS
  • Zoetis releases update of M. Hyo Manual

    Zoetis has released an update of the comprehensive manual, “A Contemporary Review of Mycoplasma Hyopneumoniae Control Strategies,” with 14 articles developed by swine-disease experts specializing in this pathogen.

  • Start with the gilt-development unit for Mhp elimination

    US pig producers have made a big push to eliminate Mycoplasma hyopneumoniae (Mhp) from their herds as a way to capture more value in finishing pigs.

  • Multi-site study demonstrates efficacy of Draxxin® for SRD

    DISCOVERIES, Issue 11: A multi-site study of pigs with swine respiratory disease (SRD) demonstrates that one dose of Draxxin® (tulathromycin) not only lowers mortality, it can significantly improve treatment success and reduce total lung lesions.

  • M. hyo elimination or control: ‘We have the tools to succeed’

    Hog farmers and veterinarians no longer have to accept the poorer performance that results from M. hyo infection. Whether the decision is to control or eliminate M. hyo, there are numerous tools available, and the payoff is real.




You must be logged in to edit your profile.

Google Translate is provided on this website as a reference tool. However, Poultry Health Today and its sponsor and affiliates do not guarantee in any way the accuracy of the translated content and are not responsible for any event resulting from the use of the translation provided by Google. By choosing a language other than English from the Google Translate menu, the user agrees to withhold all liability and/or damage that may occur to the user by depending on or using the translation by Google.