Sign up now!
Don't show this again
Download the report!Continue to Site >
or wait 7 secs

Thank you for confirming your subscription!

(And remember, if ever you want to change your email preferences or unsubscribe, just click on the links at the bottom of any email.)

We’re glad you’re enjoying Pig Health Today.
Access is free but you’ll need to register to view more content.
Already registered? Sign In
Tap to download the app


Collect articles and features into your own report to read later, print or share with others

Create a New Report


Read Later

Create a new report

Report title (required) Brief description (optional)
follow us

You must be logged in to edit your profile.

Favorites Read Later My Reports PHT Special Reports
Pig Health Today is equipped with some amazing (and free) tools for organizing and sharing content, as well as creating your own magazines and special reports. To access them, please register today.
Sponsored by Zoetis

Pig Health Today | Sponsored by Zoetis


Field studies demonstrate safety of Fostera® Gold PCV MH vaccine

Download the PDF

Fostera® Gold PCV MH, an inactivated vaccine from Zoetis developed to provide broad protection against porcine circovirus type 2 (PCV2), has been demonstrated to be safe for pigs in field studies.

Fostera Gold PCV MH is the first and only vaccine for the US pork industry to contain both the PCV2a and PCV2b genotypes.1 Research has demonstrated a PCV2 vaccine with two genotypes provides broader in-the-field coverage against circulating PCV2 viruses2 than vaccines with only one genotype.

Three-site field study

A field study to evaluate the safety of Fostera Gold PCV MH was conducted in Texas, North Carolina and Minnesota with 750 clinically healthy pigs.3 At each location, 200 pigs received the vaccine as an intramuscular injection and 50 pigs served as unvaccinated controls.

“Handling of young pigs was kept to a minimum to avoid causing stress, but injection sites were carefully examined for swelling or irritation,” said Meggan Bandrick, DVM, PhD, research scientist, Zoetis.

The pigs were also watched for signs of health problems such as lethargy, cough or lameness. Individuals observing the pigs didn’t know which animals had or had not been vaccinated with Fostera Gold PCV MH, she said.

Safety trial results

In Texas, piglets at a commercial nursery facility received one, intramuscular 2-ml dose of Fostera Gold PCV MH in the neck. There were no injection-site reactions.

In North Carolina and Minnesota, piglets at commercial farrowing barns received 1 ml of the vaccine at 3 days of age and a second, 1-ml dose 3 weeks later after they were moved to nurseries.

To provide dosing flexibility, the split dose of the vaccine can be initiated at 3 weeks instead of 3 days of age, but at these two sites, it was initiated at 3 days of age because any reactions that might occur would be more likely to show up in young pigs, Bandrick said.

At the North Carolina site, some pigs had mild injection-site reactions after the first dose of Fostera Gold PCV MH, but so did some control animals. The reactions readily resolved. Mild injection-site reactions were also seen after the second dose of Fostera Gold PCV MH, but the pigs had received other vaccines, which made it difficult to tell which vaccine caused a reaction.

At the Minnesota site, there were no injection-site reactions after the first dose of the new vaccine. After the second dose, two animals had local reactions, which again were mild, Bandrick said. Apart from local reactions that resolved in 7 to 14 days after vaccination, there were no clinically relevant health problems in pigs attributed to Fostera Gold PCV MH, she said.

Lucina Galina, DVM, PhD, director of US Pork Technical Services, Zoetis, said she recommends two doses of the vaccine initiated at 3 weeks of age. “Two doses help ensure all pigs get vaccinated. In addition, field experience with PCV2 vaccines tells us waiting until 3 weeks of age to initiate a split-dose regimen may yield a better immune response, even though the vaccine is safe when given at a younger age.”

Second field trial

Galina said the safety of Fostera Gold PCV MH was also substantiated in a large field trial conducted at a commercial Midwest facility in Illinois. Pigs received one, 2-ml dose of Fostera Gold PCV MH at 3 weeks of age, or two, 1-ml doses initiated at 3 days or 3 weeks of age with the second dose administered 3 weeks later.

This study involved 880 pigs and was an efficacy trial comparing different PCV2 vaccines, but safety was also assessed. “Of more than 300 pigs that received Fostera Gold PCV MH, only one pig had a reaction and it was unremarkable,” the veterinarian added, noting the study demonstrated the vaccine’s efficacy against PCV2d.4

The safety of the vaccine is largely attributable to the vaccine’s adjuvant, MetaStim®. The adjuvant is smooth and stimulates antibodies as well as a strong cell-mediated response, which are both necessary to fight the virus. In addition, the vaccine’s 23-week duration of immunity against PCV2 and Mycoplasma hyopneumoniae will protect pigs through the finishing period, Galina said.


1 Data on file, Study Report No. 16 PRGBIO-01-01, Zoetis LLC.
2 EpiCC PCV2 Analysis Study, January 2018
3 Data on file, Study Report No. B921RUS-16-609, Zoetis, LLC.
4 Data on file, Study Report No. 16 PRGBIO-01-01, Zoetis LLC.



Discoveries is a series of  research news reports written by the editors of Pig Health Today on behalf of the US Pork Business of Zoetis.



All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.

©2021 Zoetis Services LLC. All rights reserved.      Rev June 2021       FSTRA-00096

Share It
Fostera® Gold PCV MH, the inactivated vaccine from Zoetis developed to provide the broadest protection available against porcine circovirus type 2 (PCV2), has been demonstrated to be safe for pigs in field studies.

Click an icon to share this information with your industry contacts.

Posted on June 9, 2021

tags: , ,

You must be logged in to edit your profile.

Google Translate is provided on this website as a reference tool. However, Poultry Health Today and its sponsor and affiliates do not guarantee in any way the accuracy of the translated content and are not responsible for any event resulting from the use of the translation provided by Google. By choosing a language other than English from the Google Translate menu, the user agrees to withhold all liability and/or damage that may occur to the user by depending on or using the translation by Google.